International Workshop
"From Homo sapiens
to Homo sapiens liberatus"

25 May
Conference Hall 221, Bldg. "B"

9:15-9:45

Registration, coffee

9:45-12:00
Chairmen, G. Blobel*, A. Olovnikov

V.P. Skulachev	9:45-10:00	Introductory remarks
V.P. Skulachev and M.V. Skulachev	10:00-10:45	The present state of the art of the SkQ Megaproject
	10:45-11:00	Discussion
B. Cannon	11:00-11:15	Multiplicity of beneficial effects of mitochondrially targeted plastoquinone on ageing phenotype in premature ageing mice with increased mitochondrial DNA mutations
	11:15-11:30	Discussion
J. Nedergaard	11:30-11:45	Mitochondrial effects of prolonged treatment of mtDNA mutator mice with SkQ
	11:45-12:00	Discussion
	12:00-12:30	Coffee break

12:30-14:30
Chairmen, B. Cannon, V.I. Kapelko

D.B. Zorov	12:30-12:45	Effects of SkQs on oxidative stress-mediated injuries of kidney and brain
	12:45-13:00	Discussion
B.V. Chernyak	13:00-13:15	SkQ1 accelerates dermal wound healing in animals
	13:15-13:30	Discussion
N.G. Kolosova	13:30-13:45	Effects of SkQ on cataract and retinopathies in OXYS rats
	13:45-14:00	Discussion
A.A. Zamyatnin	14:00-14:15	Clinical trials of the SkQ1 drops in treatment of "dry eye"
	14:15-14:30	Discussion
	14:30-15:45	Lunch

15:45-19:15
Chairmen, J. Nedergaard, E.I. Rogaev

V.N. Anisimov	15:45-16:00	Effects of SkQ on lifespan and spontaneous carcinogenesis in female mice of three different strains
	16:00-16:15	Discussion
F.F. Severin	16:15-16:30	Two mechanisms of antioxidant activity of SkQs
	16:30-16:45	Discussion
D.A. Cherepanov	16:45-17:00	Possible role of the Complex III-bound cardiolipin dimer in initiation of mitochondrial lipid peroxidation
	17:00-17:15	Discussion
S.A. Nedospasov	17:15-17:30	Unexpected features in mice with mutant cytochrome c
	17:30-17:45	Discussion
	17:45-18:15	Coffee break
J. Mitteldorf	18:15-18:30	Darwinian Evolution is a Highly Evolved Process
	18:30-18:45	Discussion
V. Gorbunova	18:45-19:00	SIRT6 promotes DNA repair under stress by mono-ADP-ribosylating PARP1
	19:00-19:15	Discussion

19:15-20:15
Chairmen, G. Libertini, L. Gavrilov

A. Seluanov	19:15-19:30	Anticancer mechanisms in a longest-lived rodent, the naked mole-rat
	19:30-19:45	Discussion
H.S. Saunders	19:45-20:00	Non-senescence in classical evolutionary theory
	20:00-20:15	Discussion
	20:15	Coffee break

26 May
Conference Hall 221, Bldg. "B"

9:00-9:30

Coffee

9:30-12:00
Chairmen, C.J. Hauser, S.A. Nedospasov

K. Lewis	9:30-9:45	Examples of prokaryotic genetic programs detrimental to individual cell
	9:45-10:00	Discussion
N. Gavrilova	10:00-10:15	Comparative analysis of parameters of human ontogenesis and senescence
	10:15-10:30	Discussion
G. Libertini	10:30-10:45	Oxidative damage and aging
	10:45-11:00	Discussion
T. Goldsmith	11:00-11:15	Rationale for complex programmed life span regulation in mammals
	11:15-11:30	Discussion
	11:30-12:00	Coffee break

12:00-14:00
Chairmen, T. Goldsmith, D. Vinogradov

E.I. Rogaev	12:00-12:15	Brain and aging
	12:15-12:30	Discussion
C.J. Hauser	12:30-12:45	Mitochondrial debris including mitochondrial DNA and formyl peptides that appear in the blood after major trauma can induce a syndrome resembling sepsis
	12:45-13:00	Discussion
A.G. Ryazanov	13:00-13:15	An enzyme whose inactivation delays aging and increases lifespan
	13:15-13:30	Discussion
	13:30-14:00	General discussion
	14:00-15:00	Lunch
POSTERS	15:00-16:00	N.A. Bocharova et al. , Role of mitochondria in cell senescence-induced death of yeast Saccharomyces cerevisiae E.K. Fetisova et al. , Induction of multidrug resistance P-glycoprotein inhibits the antiapoptotic action of mitochondria-targeted antioxidant SkQR1 L.A. Gavrilov & N.S. Gavrilova, Demographic Consequences of Defeating Aging E.N. Grigoryan et al. , The novel antioxidant SkQ1 as an effective protector of rat eye tissues during long-term organotypic cultivation D.A. Knorre et al. , Sir2-dependent daughter-to-mother transport of the damaged proteins in yeast is necessary to prevent high stress sensitivity of the daughters G. Libertini, Comparison between two paradigms about aging G. Libertini, Are C. elegans and D. melanogaster valid animal models for studies on aging? G. Libertini, Arguments against telomere-telomerase system as general defence against cancer G. Libertini, A proposal: Project "Homo sapiens liberatus II"! M. Vyssokikh et al. , Altered content and fatty acid composition in cardiolipin of mitochondria from mtDNA mutator mice L.S. Yaguzhinsky et al. , The study of uncoupling action mechanism of SkQ?SkQ3 family compounds M.A. Kozlova & A.Y. Mulkidjanian, The impact of membrane-targeted cations on energy conversion in membrane vesicles from Rb. capsulatus E.V. Titova et al. , The effect of mitochondria-targeted antioxidants on normal and transformed cells in culture G.S. Shagieva et al. , The effects of mitochondria-targeted antioxidants on human cervical cancer cells in culture
Chairman, V.P. Skulachev	16:00-17:30	Discussion on initiation of the Homo sapiens liberatus (HSL) movement
G. Blobel*	17:30-17:45	Concluding remarks
	19:00-22:00	Banquet at a Moscow river boat (starts near Radisson Royal Hotel, former "Ukraina" Hotel)

* Off sick

Homo Sapiens Liberatus Workshop, Moscow State University, May 2010

www.programmed-aging.org